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The disorders

Tinnitus or "ringing in the ears" is a phantom sound that is generated in the brain. Hyperacusis, or over-sensitivity to certain sounds, is commonly associated with tinnitus and also originates in the brain.

Impaired quality of life

Many people with tinnitus suffer from sleep disorders, difficulties concentrating, and negative affect such as anger, irritability, anxiety and depression.

No cure

Tinnitus is estimated to be the third most common health problem world-wide. Despite the significant need, there is no FDA-approved medication for lessening or ameliorating tinnitus.

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Hearing disorders

Learn more about tinnitus, hyperacusis and age-related hearing loss.

Our solution

Learn more about our scientific advances towards a cure.

 

Risk Factors

age

Meniere's disease

military service

noise exposure

stress

develop-mental

conditions

Tinnitus and Hyperacusis

Age-related hearing loss

The disorder

Age-related hearing loss (ARHL) or presbycusis is a functional loss in the ability to process sounds. For most people, this functional loss occurs in both the inner ear and in the brain. Sound processing deficits in the inner ear can be improved with current hearing aid technology. Unfortunately, some people resist wearing hearing aids. Hearing aids also do not solve sound processing deficits in the brain. Effective treatments are lacking for the component of ARHL that originates in the brain.

Hearing loss impairs quality of life

Age-related hearing loss causes difficulties in understanding speech and leads to social isolation. ARHL is associated with cognitive decline, perhaps due to social isolation.

10,000 Americans turn 65 each day

How many people have age-related hearing loss?

65 years and older

75 years and older

Our Solution

Science

Innovation

Progress

Ion channel

Success

Peptides

Hearing

Technology

Small molecules

 

Idea

Ion channels influence how brains cells, or neurons, shape the flow of information in the brain. Changes in ion channel function alter how neurons integrate and pass on electrochemical signals to other neurons. At Cognosetta, our medications development program is based on the idea that adjusting ion channel and neuroreceptor function can return neuronal signaling to normal, promoting healthy brain function and remedying disorders that originate in the brain.

Research

Our preclinical results support the utility of targeting a specific ion channel for treating hearing disorders like tinnitus and age-related hearing loss. We have shown preclinical utility for ameliorating tinnitus. In other preclinical studies, we have shown utility in improving hearing acuity and counteracting a loss of sensitivity to sounds that occurs with age. 

Small Molecule and Peptide Drug Classes

Our pipeline includes both small peptide and small molecule ion channel modulators. Our drug candidates are bioavailable to the brain, alter neuronal signaling in auditory brain areas, and alter behavioral measures of auditory function. 

Progress

Our scientists have identified a drug target and drug candidates for improving neurophysiological and behavioral measures of tinnitus and age-related hearing loss. To support the clinical success of these drug candidates our scientists are also advancing quantitative methods for evaluating the efficacy of new drug candidates that can be shared across the preclinical and clinical development stages.

Search

At Cognosetta, we value scientific research exploring ion channels as targets for neurological diseases. We are open to industry, academic, and government partnerships to validate ion channel targets and develop drug candidates that influence ion channel function.